Simple text and colorful illustrations introduce readers to the the symbiotic relationships shared by some animals, with questions and a hands-on activity.

When Arnold, one of Ms. Frizzle's students, finds a small foxlike animal with huge ears in the lost and found, he and the rest of the class join in the search for the animal's habitat. They visit six different habitats: the Arctic, the North American temperate forest, the African grasslands, the Amazon rain forest, wetlands, and desert.

The Kratt brothers travel the world learning about various animals, showcasing key science concepts along the way, and use their creature power suits to foil the plans of villains who would use the animals for monetary gain.