Dale Denton is a lazy court-process clerk and stoner. He likes to visit his equally lazy dealer Saul Silver. His purpose is to purchase weed, specifically, a rare new strain called Pineapple Express. Dale becomes the only witness to a murder by a crooked cop and the city's most dangerous drug lord. He panics and drops his roach of Pineapple Express at the scene. Dale goes back to Saul to find out if the weed is so rare that it can be traced back to...

Laguna Beach entrepreneurs Ben, a peaceful and charitable Buddhist, and his closest friend Chon, a former Navy SEAL and ex-mercenary, run a lucrative, homegrown industry, raising some of the best marijuana ever developed. They also share a one-of-a-kind love with the extraordinary beauty Ophelia. Life is idyllic in their Southern California town, until the Mexican Baja Cartel decides to move in and demands that the trio partners with them.

Five million dollars worth of California's sweetest export is up for grabs when a mysterious assailant kills the rightful owner. Now, three naive hired hands who witnessed the murder are drawn into a dangerous world of double-dealing and death threats.